Highly atroposelective synthesis of nonbiaryl naphthalene-1,2-diamine N-C atropisomers through direct enantioselective C-H amination
نویسندگان
چکیده
منابع مشابه
Catalytic, highly enantioselective, direct amination of enecarbamates.
Amination of enecarbamates with dibenzylazodicarboxylate and oxygenated nucleophiles in the presence of a catalytic amount of chiral phosphoric acid afforded optically active stable precursors of α-hydrazinoimines, which were reduced or oxidized, respectively, to vicinal diamines or α-amino acid precursors with excellent yield and enantioselectivity.
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Iron containing monooxygenases play diverse roles in nature, ranging from the primary metabolic functions of alkane hydroxylases to the xenobiotic detoxification and secondary metabolic roles of cytochrome P450 enzymes..[1] Common to these enzymes is the ability to reductively activate molecular oxygen to generate highly electrophilic oxygen species, whose reactivity is comparable with that of ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2019
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10858-x